Dr. Ibrahim Albedaiwi ClinicGastroenterology, Hepatology & Endoscopy
Preparing for endoscopy

Colonoscopy

Content date: 14 November 2026

A colonoscopy uses a thin flexible camera to examine the rectum and colon.

What exactly is a colonoscopy?

  • A flexible camera tube is inserted through the anus to examine the rectum and colon and may reach the end of the small intestine. It allows the lining to be viewed, samples taken and many polyps removed during the same procedure. It differs from gastroscopy, which enters through the mouth.
  • Stool residue must be cleared so it does not hide details of the lining. Biopsies may be taken for chronic diarrhea even when the appearance is normal, as in microscopic colitis. Colonoscopy does not identify every cause of abdominal pain or examine most of the small intestine; your doctor selects additional tests according to the clinical question.

See the medical illustration (NIH / NIDDK)

Why is it performed?

  • To assess bleeding, inflammation or polyps, and for preventive screening when appropriate. Biopsies may be taken or polyps removed.

If you encounter a problem

  • Call the unit if you cannot finish the solution, keep vomiting, or still have dark or solid stool close to your appointment. Do not add laxatives yourself.
  • Replace fluids with permitted drinks until the drinking cutoff. If you have a fluid restriction, ask for an appropriate plan. Do not ignore severe dizziness or reduced urine.

What happens during the examination?

  • A flexible scope is inserted through the anus, and sedation may be used. Temporary mild bloating or cramps can follow. Bleeding, perforation and sedation complications are uncommon but possible, especially after treatment.

Regular medicines before endoscopy

Review your complete medicine and supplement list with the endoscopy unit at least a week before the appointment, and earlier if a longer interruption may be needed. Get a written plan for every medicine that needs adjustment.

  • Medicines that may continue: Examples include amlodipine or bisoprolol for blood pressure, levothyroxine for thyroid disease and levetiracetam for epilepsy, according to the team’s plan. Bring asthma inhalers. Fasting does not mean stopping every medicine.
  • Taking an approved dose: Use a small sip of water at the agreed time. Any dose after the drinking cutoff needs explicit instructions from the unit. Do not independently stop seizure medicines, long-term steroids or transplant medicines.
  • Medicines needing a separate plan: Insulin and diabetes medicines, including SGLT2 and GLP-1 medicines, diuretics and some heart and blood-pressure medicines. The team sets what to continue or hold and when to restart. Do not stop all insulin yourself.
  • Blood thinners: Examples include warfarin, apixaban and clopidogrel. Any interruption or adjustment needs an agreed plan from the prescribing doctor and gastroenterologist. Low-dose aspirin usually continues for most endoscopic procedures.
  • During bowel cleansing: Oral medicine absorption may decrease; ask the pharmacist about spacing from your preparation. Iron, antidiarrheal medicines or fiber supplements may need a temporary pause. Colonoscopy alone does not require stopping a PPI; the plan differs if H. pylori testing is also planned.

Full guide: my medicines before endoscopy, interruption and restarting

How do I prepare for colonoscopy?

What happens on procedure day?

  1. Check in at the endoscopy unit. The nurse reviews your preparation, fasting, medicines and allergies, checks your vital signs and places an IV line if needed for sedation or medicines.
  2. The team explains the procedure and confirms your consent. The examination itself often takes around half an hour in this clinic. It may take longer if treatment is needed.
  3. After sedation, expect about an hour in recovery. The team checks how you are doing and decides when it is safe to go home. Check-in and recovery add to the total time at the unit.

The doctor uses the scope to diagnose problems and can treat some of them during the same examination. Based on the findings and the agreed plan, the doctor may take small tissue samples (biopsies), stop bleeding, remove polyps, widen a narrowed area in selected cases, or perform another treatment if needed.

What to expect with moderate sedation

A sedative is usually given through a vein. You may feel relaxed and sleepy, and you can usually respond to your name or a simple request. You generally breathe on your own and may remember little of the examination. The team monitors breathing, oxygen level, pulse and blood pressure. Tell the team if you feel pain or discomfort. Your team will discuss whether an examination without sedation, moderate sedation, deeper sedation or another option is most suitable for you.

Possible complications

Serious complications of routine diagnostic endoscopy, such as perforation, are very rare. Serious complications from sedation are also very rare. The procedure can cause bleeding or a tear in the wall (perforation), and infection is possible. Sedation can lower oxygen or blood pressure, and stomach contents can enter the lungs (aspiration). The team monitors for these problems and treats them promptly. Risk varies with your health and what is done during the procedure. In screening colonoscopy, one evidence review estimated about 3 perforations and 15 bleeding events per 10,000 procedures. Risk can be higher when polyps are removed. In a large endoscopy registry using different sedation methods, serious sedation complications occurred in about 1 in 10,000 procedures. Brief drops in oxygen or blood pressure can be more frequent.

When to get help

Severe pain with swelling or inability to pass gas, heavy bleeding or clots, fainting, fever or breathlessness after the procedure; or severe dehydration during preparation.

If your medicine or fasting instructions are unclear, call the endoscopy unit before starting preparation.

Guides for your care journey

Read the related guides together:

Related guides

My medicines before endoscopy

Colonoscopy preparation instructions

Colon polyps

After colon polyp removal and biopsy results

Gastrointestinal bleeding

Understanding endoscopy and biopsy results

Sources

ASGE: Bowel preparation

ASGE: Preparation recommendations

NIDDK: Colonoscopy

ASGE: Diabetes and weight-management medicines before endoscopy 2025

Multisociety recommendations: Individualizing the GLP-1 plan

USMSTF: Bowel preparation 2025

ASGE / USMSTF bowel preparation 2025

ASGE: Eating after colonoscopy

NHS: Low-fiber food examples

PICOPREP: trial of product-specific tailored dosing

Saudi FDA: PICOPREP product registration

Moviprep — prescribing information

BSG: Sedation in gastrointestinal endoscopy