Glecaprevir/pibrentasvir for hepatitis C
Content date: 11 November 2026
An oral hepatitis C treatment known as Maviret or Mavyret. Each tablet contains two medicines; the usual adult dose requires three tablets together.
Your next step
Check your written prescription and monitoring plan. If anything is unclear, ask your care team before changing a dose.
Get urgent help: Get urgent help for new jaundice, abdominal swelling, confusion, vomiting blood, black stools or breathing difficulty.
How to use
- Take three 100/40 mg tablets together once daily with food. Treatment is often eight weeks for suitable previously untreated adults, but prior therapy and clinical circumstances can require longer. Do not spread the tablets through the day. For a missed dose or vomiting after dosing, use your leaflet or call the pharmacist; never double.
Storage
- The Saudi-registered Maviret pack specifies below 30°C. Follow the instructions on your own pack, retain its packaging, and keep away from children and heat.
Tests and follow-up
- Before treatment, assess liver function/scarring, kidney function and HCV RNA, and test for HIV and hepatitis B. HBV can reactivate during or after treatment and needs a monitoring plan. An undetectable HCV RNA result at least 12 weeks after treatment completion confirms cure.
Possible side effects: what to expect
- Not everyone gets side effects. Headache, tiredness or nausea may occur; most reactions in trials were mild or moderate. Take your prescribed dose with food and contact the team if symptoms persist or interfere with completing treatment.
- Serious liver deterioration can occur, particularly with advanced liver disease, so liver assessment is essential before prescribing. New jaundice, abdominal swelling or confusion needs urgent assessment. Other medicines and hepatitis B reactivation risk are also reviewed.
Important
- It contains a protease inhibitor: do not use with moderate/severe liver impairment or previous decompensation such as ascites, variceal bleeding or hepatic encephalopathy. Review all medicines, especially rifampicin, atazanavir, statins, seizure medicines and St John’s wort. Ethinylestradiol-containing contraception requires review because restrictions differ by label. Discuss pregnancy and breastfeeding.
My prescribed plan - complete with the team
Brand / device: ........................ | Dose and how I take or use the medicine: ........................
Next dose: ........................ | Next blood tests: ........................
Team contact: ........................
Brand / device: ........................ | Dose and how I take or use the medicine: ........................
Next dose: ........................ | Next blood tests: ........................
Team contact: ........................
When to get help
Get urgent help for new jaundice, abdominal swelling, confusion, vomiting blood, black stools or breathing difficulty.
Contact the clinic for persistent headache, fatigue or nausea, repeated missed doses, or difficulty completing treatment.