Ledipasvir/sofosbuvir for hepatitis C
Content date: 11 November 2026
An oral hepatitis C treatment known as Harvoni. It suits particular viral genotypes and clinical situations; your clinician selects the duration and any additional medicines.
Your next step
Check your written prescription and monitoring plan. If anything is unclear, ask your care team before changing a dose.
Get urgent help: Get urgent help for fainting, a markedly slow heartbeat, chest pain, breathlessness, new jaundice or confusion.
How to use
- The usual adult dose is one 90/400 mg tablet daily, with or without food, often for 12 weeks. Selected situations require a shorter or longer course. Do not stop early because symptoms improve. For a missed dose or vomiting after dosing, follow the product leaflet or ask the pharmacist; never double.
Storage
- Follow the temperature requirement on your dispensed pack and retain the original container. Product labels can differ. Keep away from children and heat; do not leave it in a hot car.
Tests and follow-up
- Before treatment, check HCV RNA and genotype, assess liver disease and kidney function, and test for HIV and hepatitis B. HBV may reactivate during or after treatment. An undetectable HCV RNA result at least 12 weeks after treatment completion confirms cure.
Possible side effects: what to expect
- Not everyone gets side effects. Headache, tiredness or nausea may occur and are often mild. Discuss persistent symptoms or those limiting your activities; check before adding pain relief or heartburn medicines to ensure they suit your treatment.
- Important problems can result from interactions, particularly a slow heartbeat when combined with amiodarone. Hepatitis B reactivation risk also needs assessment. If ribavirin is added, its pregnancy precautions and anaemia monitoring apply.
Important
- Acid-reducing medicines need planning: separate ordinary antacids by four hours and check before omeprazole or famotidine. Review amiodarone, statins, seizure medicines, rifampicin, St John’s wort and HIV medicines, particularly those containing TDF. Check before adding medicines. Discuss pregnancy/breastfeeding and read the ribavirin card if it is added.
My prescribed plan - complete with the team
Brand / device: ........................ | Dose and how I take or use the medicine: ........................
Next dose: ........................ | Next blood tests: ........................
Team contact: ........................
Brand / device: ........................ | Dose and how I take or use the medicine: ........................
Next dose: ........................ | Next blood tests: ........................
Team contact: ........................
When to get help
Get urgent help for fainting, a markedly slow heartbeat, chest pain, breathlessness, new jaundice or confusion.
Contact the clinic for persistent headache, fatigue or nausea, repeated missed doses, or a new need for heartburn treatment.