Sofosbuvir + daclatasvir for hepatitis C
Content date: 11 November 2026
Two antiviral medicines used together to cure hepatitis C. This is a usual first choice in our clinic for suitable patients.
Your next step
Check your written prescription and monitoring plan. If anything is unclear, ask your care team before changing a dose.
Get urgent help: Get urgent help for fainting, a slow heartbeat, chest pain, breathlessness, new jaundice or confusion.
How to use
- The usual adult prescription is sofosbuvir 400 mg plus daclatasvir 60 mg once daily, commonly for 12 weeks in previously untreated patients without cirrhosis. Daclatasvir can be taken with or without food; some sofosbuvir products require food, so follow your leaflet. Complete both medicines as prescribed. For a missed or vomited dose, follow each product’s leaflet or ask the pharmacist; never double.
Storage
- The SFDA-listed Sovira and Levera packs specify below 30°C. Follow your own packs, retain original packaging and keep away from children and heat.
Tests and follow-up
- Before treatment: assess liver scarring, blood count, liver/kidney function, HCV RNA, HIV and hepatitis B. HBV can reactivate during or after treatment and needs a follow-up plan. Undetectable HCV RNA at least 12 weeks after completion confirms cure.
Possible side effects: what to expect
- Not everyone gets side effects. Tiredness, headache or nausea may occur and are usually mild. Plan rest and regular meals; contact your team if symptoms persist or interfere with treatment rather than stopping either medicine yourself.
- Interactions need review before treatment, especially amiodarone, which can dangerously slow the heartbeat. Hepatitis B screening and follow-up when needed help detect reactivation. Added ribavirin requires extra precautions for anaemia and pregnancy.
Important
- Cirrhosis or previous treatment failure may require longer treatment, ribavirin or a different regimen. Check every medicine and supplement: amiodarone can cause dangerous slowing of the heartbeat; rifampicin, some seizure medicines and St John’s wort can undermine treatment. Some HIV medicines, antibiotics and antifungals may require a different daclatasvir dose; never adjust it yourself. Discuss pregnancy and breastfeeding.
My prescribed plan - complete with the team
Brand / device: ........................ | Dose and how I take or use the medicine: ........................
Next dose: ........................ | Next blood tests: ........................
Team contact: ........................
Brand / device: ........................ | Dose and how I take or use the medicine: ........................
Next dose: ........................ | Next blood tests: ........................
Team contact: ........................
When to get help
Get urgent help for fainting, a slow heartbeat, chest pain, breathlessness, new jaundice or confusion.
Contact the clinic for persistent headache, fatigue or nausea, repeated missed doses, or a new medicine.